BTEP AI in Biomedical Research @ NIH Seminar Series

CARD is a collaborative initiative of the National Institute on Aging and the National Institute of Neurological Disorders and Stroke that supports basic, translational, and clinical research on Alzheimer’s disease and related dementias. CARD’s central mission is to initiate, stimulate, accelerate, and support research that will lead to the development of improved treatments and preventions for these diseases.

Kerry Goetz, Ph.D.

David M. Reif, Ph.D., joined the NIEHS in 2022 as Chief of the Predictive Toxicology Branch (PTB) in the Division of Translational Toxicology (DTT). In this role, he will leverage expertise of the branch in data science, toxicogenomics, spatiotemporal exposures and toxicology, computational methods development, and new approach methods (NAMs) to advance predictive toxicology applications with partners across NIEHS, the interagency Tox21 Program and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM).

Although generative artificial intelligence (AI), a’la ChatGPT, is receiving a lot of “attention” these days, there are many other options for using AI to support biomedical research.  In order to help analyze and interpret single cell genomics data, we have found that AI approaches that retain “explainability” are especially useful in providing functional insights into the underlying biological systems being studied, in this case, the human brain.

Artificial Intelligence (AI) is becoming increasingly ubiquitous in biomedical research, enabled by large datasets, new algorithms, and hardware improvements. In this session, Dr. Brian Ondov will introduce the basic principles of AI and describe how its various forms can help researchers in different ways, including image classification, sequence-based prediction, generative models, and language understanding.