ncibtep@nih.gov

Bioinformatics Training and Education Program

Somatic Variant Analysis and Detection Using Localized Genome Graphs

Somatic Variant Analysis and Detection Using Localized Genome Graphs

 When: Feb. 28th, 2024 10:00 am - 11:00 am

Learning Level: Any

To Know

Where:
Online Webinar
Organizer:
CBIIT
Presented By:
Giuseppe Narzisi (New York Genome Center)
This class has ended.

About this Class

In this seminar, you'll learn about the somatic variant caller named Lancet. This accurate, open-source tool leverages local assembly and joint analysis of tumor-normal, paired, high-throughput sequence data.

New York Genome Center’s Dr. Giuseppe Narzisi will provide an overview of:

  • the methodology behind the tool.
  • how it’s benchmarking against similar tools.
  • improvements in computational performance.
  • recent integrations with third party tools to visually inspect the somatic variants in graph space.

Dr. Narzisi will also give a historical review of alignment-based methods. He’ll highlight limitations and the need for new genome graph approaches.