Somatic Variant Analysis and Detection Using Localized Genome Graphs

About this Class

In this seminar, you'll learn about the somatic variant caller named Lancet. This accurate, open-source tool leverages local assembly and joint analysis of tumor-normal, paired, high-throughput sequence data.

New York Genome Center’s Dr. Giuseppe Narzisi will provide an overview of:

• the methodology behind the tool.
• how it’s benchmarking against similar tools.
• improvements in computational performance.
• recent integrations with third party tools to visually inspect the somatic variants in graph space.

Dr. Narzisi will also give a historical review of alignment-based methods. He’ll highlight limitations and the need for new genome graph approaches.

The Data Science Seminar Series presents talks from innovators in the cancer research and informatics communities both within and outside of NCI.