Gene Symbol	Fold Change ICN1-HA vs GFP
HES4	170.4
P2RY2	86.1
CR2	60.3
CHI3L2	40.2
DTX1	37.5
TEKT4	36.3
HEY1	32.3
ALDH1A1	18.9
GCNT1	15.4
BAIAP2	12.6
NOTCH1	12
RGS6	11
C12orf42	11
XYLT1	10.2
CD8A	9.6
DNASE1L3	8.6
TCF7	8.5
FGR	8.5
NT5E	8
RAB11FIP4	8
MYOM2	7.7
JAK1	7.6
ATP2B4	6.1
MOB3B	6.1
IL18R1	6
FBN2	6
TPPP	6
CD7	6
MYBL1	5.8
HES2	5.7
SYTL3	5.7
SLC37A2	5.5
CD300A	5.5
FAIM	5.5
SPSB1	5.4
JAG1	5.3
ABCB4	5.3
GBP4	5.2
LY86-AS1	5.2
CD3E	5
GPR155	4.7
IRAK2	4.4
RAB11FIP1	4.3
MX2	4.1
BZRAP1	4.1
DFNB31	4
RIN3	4
FRMPD2	3.9
IGFBP4	3.9
LAMP3	3.8
BCL3	3.7
CPA4	3.7
GLIPR1	3.6
ASCL1	3.5
DUSP5	3.4
FAM49A	3.2
RND3	3.2
CPPED1	3.2
LOC648987	3.1
IL4I1	3.1
ZFP36L1	3.1
UST	3
CLIC6	2.9
ATF3	2.8
HERC6	2.8
CFLAR	2.7
PLAC8	2.7
HAVCR2	2.7
FSTL5	2.7
ABI3	2.6
NCF1C	2.6
IGF1R	2.6
ZDHHC14	2.5
ETS1	2.5
LOC100506639	2.5
CD27	2.4
ST3GAL5	2.4
LGALS17A	2.4
ADAM19	2.4
PASK	2.4
HES1	2.4
BCL2L11	2.3
C3orf52	2.3
NR4A1	2.3
PANK1	2.3
TASP1	2.3
LY86	2.3
CASZ1	2.3
SEMA7A	2.2
SYNE2	2.2
ITPKB	2.2
HECW2	2.2
CDK17	2.2
CABLES1	2.2
PTP4A3	2.2
CXCR4	2.2
PGM5P2	2.2
GRAMD1B	2.2
IL1R2	2.2
ARHGEF7	2.1
DUSP16	2.1
USP11	2.1
CCR7	2.1
BACH1	2.1
CHST2	2.1
CELSR1	2.1
SASH3	2.1
PIK3R1	2
KIAA0922	2
LSAMP	2
NCALD	2
LOC283710	2
GPR15	2
AKNA	2
SSH1	2
STARD10	2
EBI3	2
ENTPD1	2
ID3	2
ALPK2	2
ARHGAP10	2
SNX29	2
TBC1D9	2
PRR18	2
RALGPS1	2
FAM53B	1.9
SESN1	1.9
RABGAP1L	1.9
NCOA1	1.9
IL10RA	1.9
HIRA	1.9
GPR132	1.9
MAP3K8	1.9
CBR4	1.9
OXR1	1.9
SLC46A3	1.9
MALT1	1.9
IL7	1.9
CALCOCO1	1.8
TLE4	1.8
GNGT2	1.8
ZRANB1	1.8
SERPINI1	1.8
DENND2D	1.8
RNF19B	1.8
H6PD	1.8
MAP3K1	1.8
IRF8	1.8
ISG20	1.8
IFNGR1	1.8
FAM65B	1.8
MMD	1.8
IL15	1.8
PTK2B	1.8
RUNX3	1.7
DLGAP4	1.7
BLNK	1.7
STRADB	1.7
CEP120	1.7
ZMYND8	1.7
TMCC3	1.7
DNASE2	1.7
DYNLT1	1.7
WDTC1	1.7
PINK1	1.7
RXRA	1.7
AKAP13	1.7
PLEKHA2	1.7
MIDN	1.7
BCAT1	1.7
RORA	1.7
AUTS2	1.7
OCLN	1.7
IL6ST	1.7
LRRC1	1.7
KLHL24	1.6
GHR	1.6
PDLIM1	1.6
SERTAD1	1.6
RRAS	1.6
RAB5B	1.6
HIST1H2BK	1.6
NFKBIA	1.6
SMPD2	1.6
NRIP1	1.6
TTF2	1.6
LPP	1.6
OSTF1	1.6
SSH2	1.6
CPD	1.6
PTP4A2	1.6
C2orf42	1.6
TMEM140	1.6
UBE2G1	1.5
CPNE5	1.5
CRYZ	1.5
GALNT10	1.5
TMOD1	1.5
ARL2BP	1.5
RAD23B	1.5
ZNF318	1.5
SH3RF1	1.5
ARAP2	1.5
IER5	1.5
BCL2	1.5
REEP5	1.5
NLRC5	1.5
STK17A	1.5
PACSIN2	1.5
ALG2	1.5
EIF2AK4	1.5
PFKFB3	1.5
VASP	1.5
TNFRSF14	1.5
ZHX2	1.5
HIVEP2	1.5
RFTN1	1.5
PPP1R9B	1.5
DLG1	1.5
FNBP1	1.5
ZNF398	1.5
CLDND1	1.4
KLF6	1.4
MS4A1	1.4
ATF5	1.4
PPARA	1.4
RBM38	1.4
METTL8	1.4
CD80	1.4
ZFP90	1.4
PSME4	1.4
JUNB	1.4
SCYL3	1.4
ETV6	1.4
SH3BP5	1.4
CCDC167	1.4
DDX59	1.4
MCL1	1.4
ELF2	1.4
CPOX	1.4
KIAA0226	1.4
CHD1L	1.4
FAM134C	1.4
UBL7	1.4
BAD	1.4
TTPAL	1.4
FBXO18	1.4
MAP3K5	1.4
SLC38A1	1.4
HERPUD2	1.4
TRIP4	1.3
JMJD1C	1.3
ST6GAL1	1.3
GADD45B	1.3
MUM1	1.3
BAZ2A	1.3
CCNY	1.3
PHF12	1.3
FBXL17	1.3
GBP1	1.3
SQRDL	1.3
DDX3Y	1.3
STX11	1.3
IRF2	1.3
YWHAZ	1.3
M6PR	1.3
NCOA3	1.3
SP100	1.3
HIST1H1C	1.3
NR3C1	1.3
EPC1	1.2
TMEM43	1.2
RBM5	1.2
PTPN6	1.2
UBE2E3	1.2
DHRS7	1.2
SMARCE1	1.2
ESYT2	1.2
RNF130	1.2
KIAA0247	1.2
PHF2	1.2
PPP1CA	1.2
CD53	1.2
CDK19	1.2
BTG2	1.2
NHLRC3	1.2
BLK	1.2
TPM4	1.2
PABPC1	1.2
PLEK	1.2
ERAP2	1.2
	
	
Note: the NOTCH1 target MYC was not upregulated by ICN1 in the MO1043 cell line (due to its already high basal expression levels). The GSEA results depicted in Fig.4 were unchanged with or without MYC in the tested NOTCH1 CLL signature.