The Cancer Genome Atlas (TCGA) is a large-scale study that has catalogued genomic data accumulated from more than 20 different types of cancer including mutations, copy number variation, mRNA and miRNA gene expression, and DNA methylation. Being publicly distributed, it has become a major resource for cancer researchers for target discovery, biological interpretation and assessment of the clinical impact of genes of interest. This workshop will familiarize the audience with the types of data available and analytical tools that enable end-users to easily and effectively mine TCGA data. It will provide training on two applications: (a) cBioPortal for Cancer Genomics, an open-source tool, and (b) TCGA Premier through BioDiscovery Nexus, an NCI-licensed commercial tool.