Library ChiP preparation: Is the sequencing depth based on the organism you’re working with? Questions › Category: ChIP-Seq Data Analysis › Library ChiP preparation: Is the sequencing depth based on the organism you’re working with? 0 Vote Up Vote Down stonelakeak@nih.gov Staff asked 3 years ago Is the sequencing depth based on the organism you’re working with? 1 Answers 0 Vote Up Vote Down stonelakeak@nih.gov Staff answered 3 years ago Yes. You would not need to do the same amount of sequencing to get to same level (X-coverage) in Yeast vs Human libraries. – answered by Tovah Markowitz, Paul Schaughency, Vishal Koparde. Please login to submit your answer Login