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Bioinformatics Training and Education Program

may, 2021

17may11:00 am12:00 pmSingle cell profiling of T cell responses in non small cell lung cancer


Event Details

For our next meeting we will be having a guest lecture by Dr. Josh Waterfall from Institut Curie.


Non small cell lung cancers (NSCLC) are known to be recurrently infiltrated by multiple immune populations. Furthermore, the level of infiltration by T cell populations is a positive prognostic factor and immune checkpoint blockade provides significant clinical benefit in a subset of patients.  However, many questions remain concerning the heterogeneity and function of tumor infiltrating T cell populations.  To address these issues, we performed single cell RNA and T Cell Receptor (TCR) seq profiling of T cell subsets in a cohort of early stage NSCLC patients including tumor, juxta-tumor tissue, and blood.  This allowed development of a working model for the ontogeny, recruitment, and differentiation of these populations as well as the role of TCR signaling and proliferation within the tumor microenvironment.

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Meeting ID: 161 099 0767

Passcode: 945612

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(Monday) 11:00 am - 12:00 pm




CDSLNCI CCR Cancer Data Science LabArati Rajeevan,

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