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Bioinformatics Training and Education Program

may, 2021

17may11:00 am12:00 pmSingle cell profiling of T cell responses in non small cell lung cancer

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Event Details

For our next meeting we will be having a guest lecture by Dr. Josh Waterfall from Institut Curie.

Abstract:

Non small cell lung cancers (NSCLC) are known to be recurrently infiltrated by multiple immune populations. Furthermore, the level of infiltration by T cell populations is a positive prognostic factor and immune checkpoint blockade provides significant clinical benefit in a subset of patients.  However, many questions remain concerning the heterogeneity and function of tumor infiltrating T cell populations.  To address these issues, we performed single cell RNA and T Cell Receptor (TCR) seq profiling of T cell subsets in a cohort of early stage NSCLC patients including tumor, juxta-tumor tissue, and blood.  This allowed development of a working model for the ontogeny, recruitment, and differentiation of these populations as well as the role of TCR signaling and proliferation within the tumor microenvironment.

Join ZoomGov Meeting

https://nih.zoomgov.com/j/1610990767?pwd=NzVWQzlNOTBtazJYcFBycEEyRDJVQT09

Meeting ID: 161 099 0767

Passcode: 945612

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+16692545252,,1610990767#,,,,*945612# US (San Jose)

+16468287666,,1610990767#,,,,*945612# US (New York)

 

Time

(Monday) 11:00 am - 12:00 pm

Location

Online

Organizer

CDSLNCI CCR Cancer Data Science Lab

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