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Bioinformatics Training and Education Program

november, 2020

16nov11:00 am12:00 pmProteomic analysis of cancer internal heterogeneityCDSL Webinar

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Cancer heterogeneity is one of the major challenges that hampers the ability to cure the
disease. Tumors differ in their genetic profiles and the cellular interactions in the
microenvironment, and each tumor may have multiple different clones with distinct molecular
characteristics. Therefore understanding cancer heterogeneity has major translational
implications. In my lab we use mass spectrometry-based proteomics to understand cancer
heterogeneity in breast cancer and melanoma. We combine analysis of clinical samples with
histopathological analysis and functional validations, to unravel novel regulators of cancer
progression. Analysis of hundreds of breast cancer tumor regions associated between clinical
parameters and the protein networks, and showed their heterogeneity within single tumors.
Our research showed the importance of each clinical feature and the significance of the immune
system in affecting tumor heterogeneity. We also showed the microenvironment effects on
melanoma, in the context of immunotherapy response. These unsupervised proteomic networks set the basis for future improved therapy and precision oncology.

Presenter:
Dr. Tami Geiger, from the Sackler Faculty of Medicine, Tel Aviv University, Israel.

Meeting ID: 916 3499 0819
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Meeting ID: 916 3499 0819

Time

(Monday) 11:00 am - 12:00 pm

Location

Online

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