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Bioinformatics Training and Education Program

october, 2021

14oct1:00 pm2:00 pmNew Functional Genomic Approaches in Human Cancer ModelsBTEP Distinguished Speakers Seminar Series, Neville SanjanaMeeting Link

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Event Details

Presenter:

Neville Sanjana, Ph.D.
Assistant Professor of Biology
Neuroscience and Physiology
NYU School of Medicine and Core Faculty Member
New York Genome Center

Forward genetic screens using CRISPR (clustered regularly interspaced short palindromic repeats)–associated nucleases like Cas9 are a powerful tool to pinpoint genes involved in disease. Initial screens capitalized on genome-scale libraries to perturb nearly all protein-coding genes in the human genome to examine therapeutic resistance and gene essentiality in cancer cell lines.

Dr. Sanjana’s lab has further developed the CRISPR screening toolbox in several new directions, including in vivo screens to understand drivers of lung metastasis, saturation mutagenesis of noncoding regions to identify functional elements that drive chemotherapeutic resistance in melanoma, and screens that dissect complex interactions between tumor cells and primary immune cells in cancer immunotherapy. Recently, they developed the first RNA-targeting CRISPR screens in melanoma and combined CRISPR perturbations of chromatin modifiers with single-cell measurements of chromatin accessibility. Taken together, these new frontiers expand the potential of CRISPR screens for fundamental genomic discovery, gene regulation, and therapeutic development to overcome drug resistance.

Meeting Link

Meeting Link

Time

(Thursday) 1:00 pm - 2:00 pm

Location

Online

Organizer

BTEPBioinformatics Training and Education Program, CCR, NCINCIBTEP@mail.nih.gov

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