CIViC (Clinical Interpretation of Variants in Cancer, www.civicdb.org) is a free and open resource for curation and distribution of cancer variant knowledge which employs crowdsourced curation and expert moderation from published literature and meeting abstracts. The CIViC data model incorporates structured fields for variant classification which reflect field-wide guidelines including AMP/ASCO/CAP standards for somatic variants and ClinGen/CGC/VICC recommendations for evaluation of variant oncogenicity. CIViC is utilized by ClinGen Somatic Cancer Variant Curation Expert Panels (SC-VCEPs) to define new standards for domain specific variant classification. The CIViC data model is currently expanding to incorporate multi variant Molecular Profiles, for clinical interpretation of co-occuring variants from different genes.

Speaker:

Arpad Danos Ph.D., Washington

University in St. Louis