During this seminar, Dr. Clemens Grassberger will highlight:

• current computational and mathematical approaches for modeling the impact of radiotherapy on the immune system, and
• how to design the next generation of combination trials.

The increasing use of radiotherapy in multi-modality approaches, together with targeted biological agents, have emphasized the need for treatment response models encompassing the entire cancer treatment, not only radiotherapy. When combining radiotherapy with immunotherapeutic approaches, there is now a focus on evaluating the effects of radiation on the patient’s immune response, in addition to the direct biological effects of radiation on the tumor.