Decoding Chromatin States in T Cell Dysfunction and Modeling Gene Regulation

Recording Link CD8 T cell dysfunction is observed in diverse settings of chronic antigen exposure, including in cancer and chronic viral infection. We carried out a unified analysis of over 300 ATAC-seq and RNA-seq experiments across studies of CD8 T cell dysfunction in cancer and infection to define a shared differentiation trajectory towards terminal dysfunction … Continue reading Decoding Chromatin States in T Cell Dysfunction and Modeling Gene Regulation